AB0753 Potential of cardio-thoracic ratio measured on chest radiography for the prediction of pulmonary hypertension: correlation with pulmonary arterial systolic pressure estimated by echocardiography. (23rd January 2014)

• Record Type: Journal Article
• Authors: Lee, S. Y.; Lee, S. W.; Chung, W. T.; Bae, J. H.
• Is Part Of: Annals of the rheumatic diseases. Volume 72:Supplement 3(2013)
• Page Start: A1019
• Page End: A1019
• Publication Date: 2014-01-23
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2013-eular.3075
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Currently, there are no data on the association between pulmonary hypertension and chest radiography changes specific for idiopathic pulmonary arterial hypertension in lupus. Therefore, we aimed to assessthe correlation of cardio-thoracic (CT) ratiomeasured by chest radiography for predicting pulmonary hypertension estimated by echocardiography in lupus patients. Objectives: This study aims to determine whether CT ratio is increased in lupus patients with pulmonary hypertesion and its correlation with disease activity and other parameters. Methods: 105 patients (median 42.75±2.14 years; 10 male) who had undergone chest radiography and echocardiography were divided into two groups (hypertensive and normotensive) based upon an echocardiography-derived pulmonary arterial systolic pressure (PASP) of 25 mmHg. CT ratio was measured twice. 1 st CT ratio was calculated at the time of enrolled trial and 2 nd CT ratio was calculated after two years later. Difference between 1 st and 2 nd measured CT ratio, 1 st CT ratio and 2 nd CT ratio were then correlated with PASP using regression analysis. The Area Under the Curve (AUC) for predicting pulmonary hypertension on CT ratio was calculated. Results: In the pulmonary hypertensive group, the mean PASP was 53.13±7.76 mmHg (39-104 mmHg) and there was statistical strong correlation between the increased 2 nd cardiothoracic ratios and PASP (OR=0.228 p=0.002) but, not correlation with 1 st cardiothoracic ratio (OR=-0.055 p=0.462) and difference between 1 st and 2 nd CT ratio (OR=0.044 p=0.472). Interstitial lung disease in lupus patients were associated with PASP (OR=0.277 p=0.002) statistically. The intraobserver and interobserver correlation coefficients for cardiothoracic ratios were 0.990 and 0.892. The AUC for predicting pulmonary hypertension over 25 mmHg by echocardiography was 0.668 in 1 st CT ratio (P>0.05), 0.918 in 2 nd CT ratio and 0.919 in difference between 1 st and 2 nd CT ratio (P<0.05). Conclusions: Increased CT ratios of chest radiography was correlated statistically well with PASP estimated by echocardiography and could be used to predict pulmonary hypertension over 25 mmHg with high sensitivity and specificity. Acknowledgements: Pulmonary hypertension in systemic sclerosis and systemic lupus erythematosus. S.R. Johnson, J.T. Granton, Eur Respir Rev 2011; 20: 122, 277–286. Disclosure of Interest: None Declared