Cisplatin-Based Radiochemotherapy Improves the Negative Prognosis of c-erbB-2 Overexpressing Advanced Cervical Cancer. Issue 1 (1st January 2010)

• Record Type: Journal Article
• Authors: PÉRez-Regadera, José; SÁNchez-MuÑOz, Alfonso; De-La-Cruz, Javier; BallestÍN, Claudio; Lora, David; GarcÍA-MartÍN, Rosa; Alonso-CarriÓN, Lorenzo; Mendiola, Cesar; LanzÓS, Eduardo
• Is Part Of: International journal of gynecological cancer. Volume 20:Issue 1(2010)
• Page Start: 164-172
• Page End: 164-172
• Publication Date: 2010-01-01
• Subjects: c-erb-B2 status -- Disease-free survival -- Local relapse rate -- Advanced cervical cancer -- Chemoradiotherapy; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1111/IGC.0b013e3181ad3e11
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: To determine the impact of c-erb-B2 overexpression on disease-free survival (DFS) and local relapse in patients with advanced cervical cancer (CC) receiving concurrent chemoradiotherapy treatment. Methods: A total of 136 patients with advanced CC (FIGO stage: IB2-IIA [12]; IIB [34]; IIIB [71]; IVA [19]; including both epidermoid [86] and adenocarcinoma [14]) were analyzed to determine c-erb-B2 levels by immunohistochemistry (c-erb-B2 antibody; Dako, Glostrup, Denmark). Only c-erb-B2+++ biopsies were considered positive. All patients received pelvic radiotherapy, brachytherapy, and concurrent chemotherapy with 2 different regimens: 48 patients were treated with tegafur (800 mg/d orally) and 88 with tegafur (same doses) plus 5 cycles of weekly cisplatin 40 mg/m 2 /wk intravenously. Results: A total of 32 (23.5%) biopsies were considered c-erb-B2-positive. Three-year and 5-year DFS were 61% and 58% for c-erb-B2-negative patients and 36% and 36% for c-erB2-positive patients, respectively ( P = 0.02). Patients were stratified in 4 groups according to their c-erb-B2 status and whether they received cisplatin. The group of patients with c-erb-B2 overexpression that did not receive platinum treatment had a higher rate of pelvic relapse ( P < 0.0001), associated with a decreased DFS ( P = 0.0014). Conclusions: c-erb-B2 overexpression may imply a poor prognosis for patients with advanced CC. Treatment with cisplatin-based radiochemotherapy improved outcome in these patients.