Molecular epidemiology of genital Chlamydia trachomatis infection in Shenzhen, China. Issue 4 (20th January 2012)

• Record Type: Journal Article
• Authors: Zhang, Juan-Juan; Zhao, Guang-Lu; Wang, Feng; Hong, Fu-Chang; Luo, Zhen-Zhou; Lan, Li-Na; Zhang, Chun-Lai; Peng, Yi; Liu, Xiao-Li; Feng, Tie-Jian; Chen, Xiang-Sheng
• Is Part Of: Sexually transmitted infections. Volume 88:Issue 4(2012)
• Page Start: 272
• Page End: 277
• Publication Date: 2012-01-20
• Subjects: Chlamydia trachomatis -- molecular epidemiology -- genotype -- chlamydia infection -- chlamydia serology -- infectious diseases -- systematic reviews -- antibiotic sensitivity -- gonorrhoea -- diagnosis; Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sextrans-2011-050163
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : Objective: To investigate molecular epidemiology of Chlamydia trachomatis infection among patients recruited from different clinic settings in Shenzhen, China. Methods: A total of 2534 patients from the sexually transmitted disease (STD) clinics, obstetrics and gynaecology (OBGYN) clinics and genitourinary medicine (GUM) clinics in 34 hospitals participated in the study. The C trachomatis infection was determined using COBAS Amplicor system. DNA extracted in C trachomatis -positive samples was amplified using a nested PCR based on omp A gene and then genotyped using a microsphere suspension array. Results: The overall prevalence of genital C trachomatis infection was 17.7%. The prevalence in patients at STD or GUM clinics was significantly higher than that in patients at OBGYN clinics. Being male (adjusted OR (AOR) 2.5, 95% CI 1.8 to 3.4), having no consistent use of a condom with casual partners in the past 3 months (AOR 1.7, 95% CI 1.1 to 2.8) and having any STD symptoms (AOR 3.3, 95% CI 2.0 to 5.4) were independently associated with C trachomatis infection. Eight genotypes were identified. The most prevalent genotypes were F (22.3%), E (22.0%) and D/Da (12.7%). Other genotypes were G/Ga (8.0%), J (7.3%), K (2.7%), H (2.7%) and I/Ia (0.4%). Eighty-two samples (18.3%) were infected with multiple genotypes. Genotype D/Da among patients from GUM clinics was more common than those from STD or OBGYN clinics. Infections with genotypes G and F were statistically associated with abnormal vaginal discharge (p=0.001) and being married (p=0.014), respectively. Infection with multiple genotypes was more common among patients with a higher income (p=0.011). Conclusion: A substantial prevalence of genital C trachomatis infection in Shenzhen suggests the importance of detection and treatment of the infection in high-risk groups.