Penile gangrene due to calciphylaxis: a multidisciplinary approach to a complex clinical challenge. Issue 12 (5th December 2019)

• Record Type: Journal Article
• Authors: David, Rowan; Nowicki, Jake; Lee, Jason; Dean, Nicola
• Is Part Of: BMJ case reports. Volume 12:Issue 12(2019)
• Publication Date: 2019-12-05
• Subjects: urological surgery -- plastic and reconstructive surgery -- chronic renal failure -- dialysis -- renal system; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2019-232138
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Penile calciphylaxis is a rare but clinically challenging condition to manage. While multiple treatment options have been proposed, the underlying evidence is anecdotal, and the overall prognosis remains extremely poor. We describe the case of a patient who underwent urgent debridement of a suspected gangrenous penile tip, who was intraoperatively found to have penile calciphylaxis. The necrosis progressed and the patient had a glans amputation. A non-healing wound developed, requiring reconstruction with two skin grafts using foreskin by the plastic and reconstructive surgical unit. The patient was commenced on sodium thiosulfate and his wound had completely healed 2 months following his last operation. We review the literature to determine the biochemical features, management options and outcomes in patients with penile calciphylaxis.