Unusual manifestations of type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia. Issue 11 (1st November 2000)

• Record Type: Journal Article
• Authors: Blanco, P; Viallard, J-F; Rivel, J; Leng, B; Pellegrin, J-L
• Is Part Of: Journal of clinical pathology. Volume 53:Issue 11(2000)
• Page Start: 882
• Page End: 884
• Publication Date: 2000-11-01
• Subjects: cryoglobulinaemia -- Waldenström's macroglobulinaemia -- peritoneum -- fallopian tube; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.53.11.882
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Cryoglobulinaemia in association with Waldenström's macroglobulinaemia is relatively common, ranging from 8% to 18% of cases; however, < 5% have symptoms or complications. We describe a patient with a history of cutaneous, peritoneal, and fallopian tube vasculitis related to type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia. Cytotoxic treatment was initiated (cyclophosphamide, vincristine, and prednisone) and had a good initial response. However, after the third course of chemotherapy, the patient presented with septic shock and died. Even though cryoglobulinaemia is a model of systemic vasculitis, peritoneal and fallopian tube vasculitis associated with type II cryoglobulinemia has not been described previously.