Sexually transmitted infections in persons living with HIV infection and estimated HIV transmission risk: trends over time from the DC Cohort. (6th January 2020)

• Record Type: Journal Article
• Authors: Secco, Alessandra Anna; Akselrod, Hana; Czeresnia, Jonathan; Levy, Matthew; Byrne, Morgan; Monroe, Anne; Lucar, Jose; Horberg, Michael; Castel, Amanda Derryck; Doshi, Rupali; Rivasplata, Heather; Squires, Leah; Parenti, David; Benator, Debra
• Other Names: author non-byline.; Binkley Jeffery author non-byline.; Taylor Rob author non-byline.; Rayeed Nabil author non-byline.; Akridge Cheryl author non-byline.; Purinton Stacey author non-byline.; Hou Qingjiang author non-byline.; Naughton Jeff author non-byline.; Parfitt David author non-byline.; D'Angelo Lawrence author non-byline.; Rahkmanina Natella author non-byline.; Kharfen Michael author non-byline.; Serlin Michael author non-byline.; Kumar Princy author non-byline.; Parenti David author non-byline.; Greenberg Alan author non-byline.; Jaurretche Maria author non-byline.; Wilbourn Brittany author non-byline.; Peterson James author non-byline.; Byrne Morgan author non-byline.; Ma Yan author non-byline.; Wilcox Ronald author non-byline.; Rana Sohail author non-byline.; Fernandez Ricardo author non-byline.; Hebou Annick author non-byline.; Dieffenbach Carl author non-byline.; Masur Henry author non-byline.; Bordon Jose author non-byline.; Teferi Gebeyehu author non-byline.
• Is Part Of: Sexually transmitted infections. Volume 96:issue 2(2020)
• Page Start: 89
• Page End: 95
• Publication Date: 2020-01-06
• Subjects: HIV -- sexually transmitted infection -- incidence -- chlamydia -- gonorrhoea -- syphilis; Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sextrans-2019-054216
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : Objective: A rise in incidence of STIs has been noted in the USA and in the District of Columbia (DC). We aim to describe changes in incident STIs among persons in care for HIV in Washington, DC as well as trends in HIV viral load among those with incident STIs. Methods: We conducted a retrospective DC Cohort analysis (n=7810) measuring STI incidence (syphilis, gonorrhoea and chlamydia) as well as incare viral load (ICVL) and percentage with all viral loads less than the limit of detection (%<LLOD) by year (2012–2016) among those with incident STIs. Results: From 2012 to 2016, the incidence of STIs increased: chlamydia from 2.1 to 3.4 cases/100 person-years (p=0.0006), gonorrhoea from 2.1 to 4.0 (p<0.0001), syphilis from 1.7 to 2.6 (p=0.0042) and any STI episode from 5.3 to 8.8 (p<0.0001). STI incidence rates increased for those aged 18–34 (from 13.2 to 23.2 cases/100 person-years, p<0.0001), cisgender men (from 6.5 to 11.5, p<0.0001), non-Hispanic whites (from 8.6 to 16.1, p=0.0003) and men who have sex with men (from 9.3 to 15.7, p<0.0001). During 2012–2016, the ICVL among those with incident STIs improved from 108 to 19 copies/mL and %<LLOD from 23.6% to 55.1%. However, even in 2016, younger participants, cisgender and transgender women, non-Hispanic blacks and Hispanics had higher ICVLs and lower %<LLOD. Conclusions: Rates of incident STIs rose among persons in care for HIV in Washington, DC, with improved but not optimal measures of HIV viral suppression. These findings inform focused interventions towards preventing STI transmission and ending the HIV epidemic.