Primary diffuse leptomeningeal gliomatosis: unusual MRI with non-enhancing nodular lesions on the cerebellar surface and spinal leptomeningeal enhancement. Issue 3 (1st September 2000)

• Record Type: Journal Article
• Authors: Kastenbauer, S; Danek, A; Klein, W; Yousry, T A; Bise, K; Reifenberger, G; Pfister, H W
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 69:Issue 3(2000)
• Page Start: 385
• Page End: 388
• Publication Date: 2000-09-01
• Subjects: primary diffuse leptomeningeal gliomatosis -- chronic meningitis -- magnetic resonance imaging; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.69.3.385
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : A 28 year old man presented with a 1 month history of symptoms of intracranial hypertension. Examination showed bilateral papilloedema and meningeal signs. Magnetic resonance imaging showed nodular lesions on the cerebellar and pontine surface and thickening of the thoracic spinal leptomeninges. Throughout the course of the disease, contrast enhancement was detected in the spinal leptomeninges but not intracranially. Primary diffuse leptomeningeal gliomatosis (PDLG) was diagnosed by biopsy and later confirmed on necropsy. The present case is remarkable for the nodular superficial cerebellar lesions and the absence of intracranial contrast enhancement of the leptomeninges.