Cytotoxic and antitumor peptides as novel chemotherapeutics. Issue 1 (10th August 2020)

• Record Type: Journal Article
• Authors: Luan, Xin; Wu, Ye; Shen, Yi-Wen; Zhang, Hong; Zhou, Yu-Dong; Chen, Hong-Zhuan; Nagle, Dale G.; Zhang, Wei-Dong
• Is Part Of: Natural product reports. Volume 38:Issue 1(2021)
• Page Start: 7
• Page End: 17
• Publication Date: 2020-08-10
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/d0np00019a
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : This highlight reviews the chemical and mechanistic basis of diverse natural cytotoxic peptides, emphasizing the importance of natural peptides as promising novel chemotherapeutic drugs. Abstract : Covering: up to 2020 Treatment resistance and drug-induced refractory malignancies pose significant challenges for current chemotherapy drugs. There have been increasing research efforts aimed at developing novel chemotherapeutics, especially from natural products and related derivatives. Natural cytotoxic peptides, an emerging source of chemotherapeutics, have exhibited the advantage of overcoming drug resistance and displayed broad-spectrum antitumor activities in the clinic. This highlight examines the increasingly popular cytotoxic peptides from isolated natural products. In-depth review of several peptides provides examples for how this novel strategy can lead to the improved anti-tumor effects. The mechanisms and current application of representative natural cytotoxic peptides (NCPs) have also been discussed, with a particular focus on future directions for interdisciplinary research.