Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system. Issue 9 (September 1992)

• Record Type: Journal Article
• Authors: Girlanda, P; Vita, G; Nicolosi, C; Milone, S; Messina, C
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 55:Issue 9(1992)
• Page Start: 844
• Page End: 845
• Publication Date: 1992-09
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.55.9.844
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : To evaluate distant effects of botulinum toxin, single fibre electromyography on the extensor digitorum communis muscle and six tests of cardiovascular reflexes were performed in five patients injected with BoTox (Oculinum(R) 20-130 units) for craniocervical dystonia and hemifacial spasm. Patients underwent two sessions of treatment and the second time the dosage was doubled. Botulinum toxin injection induced an increase of mean jitter value above normal limits in all cases. An increase of fibre density was recorded six weeks after the treatment. Cardiovascular reflexes showed mild abnormalities in four patients. The data confirm distant effects of botulinum toxin on neuromuscular transmission and on autonomic function.