A new cause of 'non-responsiveness' in coeliac disease?. Issue 894 (1st April 2000)

• Record Type: Journal Article
• Authors: Jennings, J S R; Wyatt, J I; Howdle, P D
• Is Part Of: Postgraduate medical journal. Volume 76:Issue 894(2000)
• Page Start: 227
• Page End: 229
• Publication Date: 2000-04-01
• Subjects: coeliac disease -- villous atrophy -- gluten sensitivity -- leukaemia; Medicine -- Periodicals; 610
• DOI: 10.1136/pmj.76.894.227
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : A 42 year old man presented with gluten-responsive coeliac disease and secondary pancreatic insufficiency. Subsequently his symptoms relapsed and repeat small intestinal biopsy showed villous atrophy and infiltration by leukaemic cells, despite continuation of a gluten-free diet. Serious causes of relapse and non-responsiveness in coeliac disease include enteropathy-associated T-cell lymphoma, ulcerative jejunitis and an end-stage hypoplastic mucosa. This is the first report of non-responsiveness due to infiltration by leukaemia.