Depletion of trace elements and acute ocular toxicity induced by desferrioxamine in patients with thalassaemia. Issue 3 (March 1988)

• Record Type: Journal Article
• Authors: De Virgiliis, S; Congia, M; Turco, M P; Frau, F; Dessi, C; Argiolu, F; Sorcinelli, R; Sitzia, A; Cao, A
• Is Part Of: Archives of disease in childhood. Volume 63:Issue 3(1988)
• Page Start: 250
• Page End: 255
• Publication Date: 1988-03
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.63.3.250
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : High doses of intravenous desferrioxamine infused over a short period of time induce a large faecal and urinary iron excretion but also produce retinal abnormalities that are characterised by decreased amplitude on electroretinography and defective dark adaptation. This regimen also results in high faecal iron, zinc, and copper excretion, and reduced granulocyte zinc concentrations and alkaline phosphatase activity. The retinal abnormalities may be related to the zinc and copper deficiency and/or iron depletion 'per se' which interferes negatively with critical iron dependent enzymes.