G105 Pregnancy and Premature Neonatal Outcomes in Vitamin D Deficiency. (7th April 2014)

• Record Type: Journal Article
• Authors: Onwuneme, C; Martin, F; McCarthy, R; Murphy, N; Kilbane, M; McKenna, MJ; Molloy, EJ
• Is Part Of: Archives of disease in childhood. Volume 99:Supplement 1(2014)
• Page Start: A44
• Page End: A45
• Publication Date: 2014-04-07
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2014-306237.105
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Background: Hypovitaminosis D is widespread among pregnant women and their infants. Recent studies implicate Vitamin D as having anti-inflammatory effects which may be beneficial in preterm infants who are at high risk of inflammatory disorders. Aim: To assess serum 25OHD status in preterm infants in NICU and their mothers and any associations between vitamin D levels and outcome. Methods: Serum 25OHD levels were prospectively evaluated by radioimmunoassay from preterm (< 32 weeks gestation) infants and their mothers at birth. 25OHD levels were correlated with outcomes in NICU including Necrotizing Enterocolitis (NEC), Retinopathy of Prematurity (ROP) and Ventilation days. Results: A total of 70 preterm infants/mothers pairs were included. 95% of preterm infants were 25OHD deficient (<50nmol/L) and 64% were severely deficient (<30nmol/L) at birth. 90% of mothers were 25OHD deficient (<50nmol/L) and 46% were severely deficient (<30nmol/L). There were no differences in mean gestational age (G.A) and birth weights (B. Wt) between preterm infants with severe deficicncy versus the remaining preterm infants. Preterm infants with severe vitamin d deficiency had a higher incidence of NEC (p = 0.03); longer duration of assisted ventilation (p = 0.04) and higher incidence of ROP (p = 0.06) (Table 1). Conclusions: Severe hypovitaminosis D is associated with adverse outcomes especially NEC and respiratory morbidity in this cohort of preterm NICU infants. Vitamin D supplemntation in pregnancy may modify these morbidities.