High IL-18 (interferon-γ inducing factor) concentration in a purine nucleoside phosphorylase deficient patient. Issue 2 (1st August 1999)

• Record Type: Journal Article
• Authors: Yamamoto, Tetsuya; Moriwaki, Yuji; Matsui, Kiyoshi; Takahashi, Sumio; Tsutsui, Hiroko; Yoshimoto, Tomohiro; Okamura, Haruki; Nakanishi, Kenji; Kurosawa, Yoshihiro; Yamaguchi, Shinya; Sasaki, Yuko; Higashino, Kazuya
• Is Part Of: Archives of disease in childhood. Volume 81:Issue 2(1999)
• Page Start: 179
• Page End: 180
• Publication Date: 1999-08-01
• Subjects: purine nucleoside phosphorylase deficiency -- interferon-γ inducing factor -- cytokines; Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.81.2.179
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : The plasma concentration of IL-18 (interferon-γ inducing factor) was severely increased in a 3 year old boy with purine nucleoside phosphorylase (PNP) deficiency. The presence and activity of IL-18 were confirmed by immunoblotting and bioassay, respectively. These results suggest that IL-18 may be abundantly produced and secreted into plasma by PNP deficient macrophages in PNP deficiency.