Exertional rhabdomyolysis in a patient with calcium adenosine triphosphatase deficiency. Issue 7 (July 1993)

• Record Type: Journal Article
• Authors: Poels, P J; Wevers, R A; Braakhekke, J P; Benders, A A; Veerkamp, J H; Joosten, E M
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 56:Issue 7(1993)
• Page Start: 823
• Page End: 826
• Publication Date: 1993-07
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.56.7.823
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : A patient with exertional rhabdomyolysis and continuously elevated serum creatine kinase (CK) was investigated. The known causes of recurrent attacks of rhabdomyolysis were ruled out by appropriate histochemical and biochemical investigations. During ischaemic exercise tests an abnormal K(+)-efflux from exercising muscles was observed. The patient was found to have a deficiency of muscular Ca(2+)-ATPase. Dantrolene sodium therapy gave relief of muscle symptoms and improved the exercise tolerance. Both the CK level and the K(+)-efflux in ischaemic forearm testing became normal on this therapy.