High grade prostatic intraepithelial neoplasia with squamous differentiation. Issue 4 (27th March 2006)

• Record Type: Journal Article
• Authors: Melissari, M; Lopez Beltran, A; Mazzucchelli, R; Froio, E; Bostwick, D G; Montironi, R
• Is Part Of: Journal of clinical pathology. Volume 59:Issue 4(2006)
• Page Start: 437
• Page End: 439
• Publication Date: 2006-03-27
• Subjects: BPH, benign prostatic hyperplasia -- HGPIN, high grade prostatic intraepithelial neoplasia -- ISH, in situ hybridisation -- PIN, prostatic intraepithelial neoplasia; high grade prostatic intraepithelial neoplasia -- squamous differentiation -- prostate cancer -- benign prostatic hyperplasia; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.2005.028241
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : An unusual variant of prostatic intraepithelial neoplasia with prominent and extensive squamous differentiation is described. The lesion was identified in the transition zone of a 79 year old man with a three year history of increasing urinary obstructive symptoms and a clinical diagnosis of benign prostatic hyperplasia who underwent simple prostatectomy. Two years after surgery, prostatic biopsies showed atrophy and mild chronic inflammation, with no evidence of malignancy. This unusual intraepithelial lesion seems not to have been described before and may represent a new variant of high grade prostatic intraepithelial neoplasia (HGPIN) with squamous differentiation.