Anti-mitochondrial antibodies in patients with Graves' disease may not signify primary biliary cirrhosis. Issue 819 (January 1994)

• Record Type: Journal Article
• Authors: Perros, P.; Palmer, J. M.; Yeaman, S. J.; Kendall-Taylor, P.
• Is Part Of: Postgraduate medical journal. Volume 70:Issue 819(1994)
• Page Start: 17
• Page End: 18
• Publication Date: 1994-01
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.70.819.17
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Two patients with Graves' disease were incidentally found to have anti-mitochondrial antibodies by immunofluorescence in the absence of symptoms, clinical signs or biochemical evidence of liver dysfunction. Anti-mitochondrial antibody titres became undetectable in both patients on follow-up. Screening of the patients' sera by immunoblotting against the purified antigens of the M2 complex was negative. We conclude that in these cases, anti-mitochondrial antibodies detected by immunofluorescence were directed against antigens other than the primary biliary cirrhosis-associated M2 complex and therefore did not signify subclinical primary biliary cirrhosis.