MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. Issue 8 (27th July 2005)

• Record Type: Journal Article
• Authors: Saitou, M; Goto, M; Horinouchi, M; Tamada, S; Nagata, K; Hamada, T; Osako, M; Takao, S; Batra, S K; Aikou, T; Imai, K; Yonezawa, S
• Is Part Of: Journal of clinical pathology. Volume 58:Issue 8(2005)
• Page Start: 845
• Page End: 852
• Publication Date: 2005-07-27
• Subjects: ABC, avidin–biotinylated horseradish peroxidase complex -- CI, confidence interval -- HR, hazard ratio -- ICC-MF, intrahepatic cholangiocarcinoma mass forming type -- IDC, invasive ductal carcinoma of the pancreas -- PanIN, pancreatic intraepithelial neoplasia -- PBS, phosphate buffered saline -- SMC, sialomucin complex; pancreatic cancer -- mucin -- immunohistochemistry -- cumulative survival rate -- multivariate analysis; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.2004.023572
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Background: Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression and patient prognosis in IDC. Aims: To investigate the prognostic significance of MUC4 expression in IDC. Methods: The expression profiles of MUC4, ErbB2, p27, and MUC1 were investigated in IDC tissues from 135 patients by means of immunohistochemistry. Results: MUC4 was expressed in 43 of the 135 patients with IDC (31.9%). The survival of 21 patients with high MUC4 expression (>20% of neoplastic cells stained) was significantly worse than that of the 114 patients with low MUC4 expression (<20% of neoplastic cells stained) (p = 0.0043). Univariate analysis showed that high MUC4 expression (p = 0.0061), large primary tumour status (>T2) (p = 0.0436), distant metastasis (p = 0.0383), lymphatic invasion (p = 0.0243), and surgical margins (p = 0.0333) were significant risk factors affecting the outcome of patients with IDC. Backward stepwise multivariate analysis showed that MUC4 expression (p = 0.0121), lymph node metastasis (p = 0.0245), and lymphatic invasion (p = 0.0239) were significant independent risk factors. ErbB2, p27, and MUC1 were not independent risk factors. Conclusions: This study shows that MUC4 expression in IDC is a new independent factor for poor prognosis and predicts the outcome of patients with IDC.