Amiodarone-induced vasculitis and polyserositis. Issue 713 (March 1985)

• Record Type: Journal Article
• Authors: Stäubli, M.; Zimmermann, A.; Bircher, J.
• Is Part Of: Postgraduate medical journal. Volume 61:Issue 713(1985)
• Page Start: 245
• Page End: 247
• Publication Date: 1985-03
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.61.713.245
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : A dose-dependent cutaneous leukocytoclastic vasculitis developed in a 34 year old man who was given amiodarone for supraventricular tachycardias resistant to other drugs. This adverse reaction disappeared within 2 weeks after discontinuation of amiodarone despite its very long half-life of 52 days in this patient. During previous treatment periods with amiodarone, the patient had experienced photosensitivity and dose-dependent polyserositis. Since high doses of amiodarone have been recently proposed for the treatment of resistant cardiac arrhythmias, dose-dependent adverse effects as described here may be encountered with increasing frequency.