(99mTc)-HM-PAO SPECT and cognitive impairment in Parkinson's disease: a comparison with dementia of the Alzheimer type. Issue 9 (September 1991)

• Record Type: Journal Article
• Authors: Spampinato, U; Habert, M O; Mas, J L; Bourdel, M C; Ziegler, M; de Recondo, J; Askienazy, S; Rondot, P
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 54:Issue 9(1991)
• Page Start: 787
• Page End: 792
• Publication Date: 1991-09
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.54.9.787
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Regional cerebral perfusion was evaluated by single photon emission tomography (SPECT) using (99mTc)-HM-PAO as a tracer, in thirty Parkinsonian patients with (n = 15) or without (n = 15) dementia, nineteen patients with dementia of the Alzheimer type (DAT) and thirteen control subjects. HM-PAO uptake was measured in the frontal, parietal, temporal and occipital cortex and tracer perfusion was expressed as cortical/cerebellar activity ratios. Regional HM-PAO ratios in nondemented Parkinsonian patients did not differ from controls, whereas in demented patients with Parkinson's disease (DPD) a significant reduction was found in the parietal, temporal and occipital cortex. Tracer uptake ratios were significantly reduced in all regions in the DAT group. Thus DPD and DAT shared a common pattern of marked posterior hypoperfusion, although the perfusion defect was greater and more extensive in the DAT patients.