Acquired subglottic stenosis caused by methicillin resistantStaphylococcus aureus that produce epidermal cell differentiation inhibitor. Issue 1 (1st January 2001)

• Record Type: Journal Article
• Authors: Yamada, Y; Sugai, M; Woo, M; Nishida, N; Sugimoto, T
• Is Part Of: Archives of disease in childhood. Volume 84:Issue 1(2001)
• Page Start: F38
• Page End: F39
• Publication Date: 2001-01-01
• Subjects: acquired subglottic stenosis -- epidermal cell differentiation inhibitor -- methicillin resistantStaphylococcus aureus -- neonates -- neonatal toxic shock syndrome-like exanthematous disease; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/fn.84.1.F38
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : Local infection of the trachea in intubated neonates is one of the main risk factors for development of acquired subglottic stenosis, although its role in the pathogenesis is unclear. Methicillin resistant Staphylococcus aureus (MRSA) is often the cause of critical illness in neonatal patients. Two cases are reported of acquired subglottic stenosis following bacterial infection of the trachea, suggesting an association with the staphylococcal exotoxin, epidermal cell differentiation inhibitor (EDIN). EDIN-producing MRSA were isolated from purulent tracheal secretions from both infants. Acquired subglottic stenosis in both cases was probably caused by delayed wound healing as the result of EDIN inhibition of epithelial cell migration.