AB0568 Application of ozonated water in oral ulcer patients with behcet's disease. (15th June 2017)

• Record Type: Journal Article
• Authors: Miao, H; Zhang, L; Zhang, G; Xu, K
• Is Part Of: Annals of the rheumatic diseases. Volume 76(2017)Supplement 2
• Page Start: 1249
• Page End: 1249
• Publication Date: 2017-06-15
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2017-eular.3371
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Behcet's disease is a systemic vasculitis disease of unknown etiology. Oral ulcer is the most common symptoms, the ulcer is various, the swelling and pain is obvious, and it is easy to recurrent, these symptoms affected the patient's diet and life seriously.Therefore, it is important to care the patients with Behcet's disease of oral ulcer.The ozonated water had many functions such as immune activation and immune regulation, it can induce the production of many cytokines, promote the repairment of oral epithelium.At the same time, the ozonated water had a direct effect on the nerve endings, it played a better analgesic effect, it was widely used in oral mucositis which induced by chemotherapy.But there were few studies about application ozonated water in the patients with Behcet's disease of oral ulcer, it was not widely used in clinical practice. Objectives: Apply the ozonated water in patients with Behcet's disease, observe the effectiveness in patients with Behcet's disease of oral ulcer. Methods: From June 2014 to June 2016, 82 cases of hospitalized patients with Behcet's disease were randomly divided into study group and control group (n=41), the control group used nursing method of gentamycin sulfate solution and nystatin solution gargle alternatively, the research group using ozonated water gargle, observe and evaluate the healing effect of two groups of patients. Results: The research group had significant improvement in healing oral ulcer and relieving pain (P<0.05). Conclusions: Ozonated water had a perfect effect in patients with Behcet's disease of oral ulcer. References: Wainstein J, Feldbrin Z, Boaz, M et al. Defficacy of ozone-oxygen therapy for the treatment of diabetic foot ulcers[J].Diabetes Technol Ther 2011;31(12):1255–1260. Kim KI, Kim JW, Lee HJ, et al. Recombinant human epidermal growth factor on oral mucositis induced by intensive chemotherapy with stem cell transplantation [J]. Am J Hematol 2013;88(2):107–112. Xiaotong Yi.The effect of ozonated water on the anti-inflammatory and wound healing of infected wound [J]. Asia Pacific Traditional Chinese medicine, 2012;8(4):331–350. Xia Wu. Effect of different nursing methods in patients with Behcet's disease of oral ulcer [J]. Southwest Military 2010;12(3):571–572. Yuan Li, Zeju Yu, Shuling Yang, et al. Effect of ozone water treatment in oral ulcer which induced by radiotherapy[J]. Chinese Journal of nursing, 2012;18(24):2956–2957. Disclosure of Interest: None declared