Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules—the SPUtNIk study. Issue 1 (14th October 2016)

• Record Type: Journal Article
• Authors: Qureshi, N R; Rintoul, R C; Miles, K A; George, S; Harris, S; Madden, J; Cozens, K; Little, L A; Eichhorst, K; Jones, J; Moate, P; McClement, C; Pike, L; Sinclair, D; Wong, W L; Shekhdar, J; Eaton, R; Shah, A; Brindle, L; Peebles, C; Banerjee, A; Dizdarevic, S; Han, S; Poon, F W; Groves, A M; Kurban, L; Frew, A J; Callister, M E; Crosbie, P; Gleeson, F V; Karunasaagarar, K; Kankam, O; Gilbert, F J;
• Other Names: author non-byline.; Clegg Andrew author non-byline.; Groves Ashley author non-byline.; Riley Richard author non-byline.; Lodge Andrea author non-byline.; Buscombe John author non-byline.; Green Theresa author non-byline.; Stone Amanda author non-byline.; Navani Neal author non-byline.; Shortman Robert author non-byline.; Azzopardi Gabriella author non-byline.; Doffman Sarah author non-byline.; Bush Janice author non-byline.; Lyttle Jane author non-byline.; Jacob Kenneth author non-byline.; van der Horst Joris author non-byline.; Sarvesvaran Joseph author non-byline.; McLaren Barbara author non-byline.; Gomersall Lesley author non-byline.; Sharma Ravi author non-byline.; Collie Kathleen author non-byline.; O'Hickey Steve author non-byline.; Tyler Jayne author non-byline.; King Sue author non-byline.; O'Brien John author non-byline.; Srivastava Rajiv author non-byline.; Lloyd-Jones Hugh author non-byline.; Beech Sandra author non-byline.; Callister Matthew author non-byline.; Scarsbrook Andrew author non-byline.; Ashford-Turner Victoria author non-byline.; Smith Elaine author non-byline.; Mbale Susan author non-byline.; Adams Nick author non-byline.; Pottinger Gail author non-byline.;
• Is Part Of: BMJ open respiratory research. Volume 3:Issue 1(2016)
• Publication Date: 2016-10-14
• Subjects: Lung Cancer -- Imaging/CT MRI etc; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Diseases -- Treatment -- Periodicals; Respiratory therapy -- Periodicals; 616.2005
• DOI: 10.1136/bmjresp-2016-000156
• Languages: English
• ISSNs: 2052-4439

Abstract

Abstract : Introduction: Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrast-enhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently. Methods and analysis: The SPUtNIk study will assess the diagnostic accuracy, clinical utility and cost-effectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) ( 18 FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS). Image acquisition and data analysis for 18 FDG-PET-CT and DCE-CT will follow a standardised protocol with central review of 10% to ensure quality assurance. Decision analytic modelling will assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs. Ethics and dissemination: Approval has been granted by the South West Research Ethics Committee. Ethics reference number 12/SW/0206. The results of the trial will be presented at national and international meetings and published in an Health Technology Assessment (HTA) Monograph and in peer-reviewed journals. Trial registration number: ISRCTN30784948 ; Pre-results.