Nocturnal intermittent hypoxia and C reactive protein among middle-aged community residents: a cross-sectional survey. Issue 6 (3rd June 2010)

• Record Type: Journal Article
• Authors: Muraki, Isao; Tanigawa, Takeshi; Yamagishi, Kazumasa; Sakurai, Susumu; Ohira, Tetsuya; Imano, Hironori; Kitamura, Akihiko; Kiyama, Masahiko; Sato, Shinichi; Shimamoto, Takashi; Konishi, Masamitsu; Iso, Hiroyasu
• Is Part Of: Thorax. Volume 65:Issue 6(2010)
• Page Start: 523
• Page End: 527
• Publication Date: 2010-06-03
• Subjects: C reactive protein -- cross-sectional studies -- hypoxia -- sleep-disordered breathing -- sleep apnoea; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thx.2009.128744
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Background: There are conflicting results for the association between obstructive sleep apnoea and raised C reactive protein (CRP) levels. A study was undertaken to investigate whether nocturnal intermittent hypoxia, a surrogate marker for obstructive sleep apnoea, was associated with CRP levels among a community-dwelling Japanese population. Methods: Among participants in the Circulatory Risk in Communities Study (CIRCS), 1422 male and 2466 female community residents aged 40–69 years were tested during sleep. No nocturnal intermittent hypoxia, mild nocturnal intermittent hypoxia and moderate to severe nocturnal intermittent hypoxia were defined using 3% oxygen desaturation index cut-off points at 5 and 15 events/h, respectively. High-sensitivity CRP levels were measured using a latex particle-enhanced immunonephelometric assay. Multivariate analysis was adjusted for age, sex, body mass index, smoking status, current alcohol intake, hypertension, hypercholesterolaemia, diabetes mellitus and menopausal status for women. Results: Multivariable-adjusted mean CRP levels among men were 0.70 mg/l (95% CI 0.65 to 0.75) for no nocturnal intermittent hypoxia, 0.82 mg/l (95% CI 0.74 to 0.89) for mild nocturnal intermittent hypoxia and 0.84 mg/l (95% CI 0.70 to 1.00) for moderate to severe nocturnal intermittent hypoxia (p for trend=0.03). The values for women were 0.59 mg/l (95% CI 0.57 to 0.62), 0.66 mg/l (95% CI 0.59 to 0.73) and 0.82 mg/l (95% CI 0.62 to 1.03), respectively (p for trend=0.008). Compared with no nocturnal intermittent hypoxia, the prevalence of a high CRP level (≥1.0 mg/l) was 1.4–1.7-fold higher for mild to severe nocturnal intermittent hypoxia in both sexes. Conclusions: Nocturnal intermittent hypoxia is associated with raised serum CRP levels among middle-aged Japanese subjects.