Propranolol for infantile haemangiomas: single centre experience of 250 cases and proposed therapeutic protocol. Issue 12 (14th August 2014)

• Record Type: Journal Article
• Authors: Solman, Lea; Murabit, Amera; Gnarra, Maria; Harper, John I; Syed, Samira B; Glover, Mary
• Is Part Of: Archives of disease in childhood. Volume 99:Issue 12(2014)
• Page Start: 1132
• Page End: 1136
• Publication Date: 2014-08-14
• Subjects: Dermatology -- General Paediatrics; Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2014-306514
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Objective: To assess the safety and efficacy of systemic propranolol for the treatment of complicated infantile haemangiomas. Design: Retrospective review of case notes of paediatric patients treated with propranolol for complicated infantile haemangiomas. Setting: Tertiary care children's hospital. Patients: All paediatric patients with complicated infantile haemangiomas who commenced treatment with propranolol from July 2008 to December 2011 and have completed treatment for at least 3 months. Results: 250 patients were treated with propranolol; 34.4% were premature and 5.6% postmature. Indications for propranolol included: vision compromise (42.0%), bleeding and/or ulceration (30.4%) airway obstruction (8.8%), feeding difficulty (8.4%), risk of permanent disfigurement (4.4%) and other (6%) (nasal obstruction, auditory canal obstruction, large haemangioma, compression of neck structure and spinal cord). Median age at beginning of treatment was 4.5 months. Median age at end of treatment was 16.7 months. Median length of therapy was 11.8 months. Adverse effects (such as wheezing, worsening of ulceration, sleep disturbance, diarrhoea) occurred in 38 patients (15.2%), leading to modifications in management in 26 patients (10.4%). 240 patients (96%) had good to excellent response to treatment. 20 patients (8%) experienced regrowth of the haemangioma on cessation of propranolol and six patients (2.4%) required propranolol to be restarted. Conclusions: In appropriately selected patients, propranolol is a safe and effective treatment for infantile haemangiomas.