Late onset parkinsonian syndrome in Hallervorden-Spatz disease. Issue 12 (December 1987)

• Record Type: Journal Article
• Authors: Alberca, R; Rafel, E; Chinchon, I; Vadillo, J; Navarro, A
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 50:Issue 12(1987)
• Page Start: 1665
• Page End: 1668
• Publication Date: 1987-12
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.50.12.1665
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Two siblings, from consanguineous parents, developed in their twenties a Parkinsonian syndrome. In the elder, the disease evolved for 13 years and the necropsic study was diagnostic of Hallervorden-Spatz disease. The younger sibling is severely affected after 12 years of the disorder. Several CT and one MR studies done in this patient during the last 4 years have been normal. Ultrastructural studies of the bone marrow histiocytes and blood lymphocytes disclosed peculiar inclusions. Bromocriptine in low doses proved to be a beneficial therapy for this patient.