Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses. Issue 1 (29th January 2016)

• Record Type: Journal Article
• Authors: Sakurai, Kenichi; Miyaso, Hidenobu; Eguchi, Akifumi; Matsuno, Yoshiharu; Yamamoto, Midori; Todaka, Emiko; Fukuoka, Hideoki; Hata, Akira; Mori, Chisato
• Other Names: author non-byline.; Sekine Akihiro author non-byline.; Fujita Shinsuke author non-byline.; Shimojo Naoki author non-byline.; Hanazato Masamichi author non-byline.; Tachibana Kaori author non-byline.; Nakaoka Hiroko author non-byline.; Otake Masae author non-byline.; Suzuki Norimichi author non-byline.; Watanabe Masahiro author non-byline.; Osada Hisao author non-byline.; Shiga Satomi author non-byline.; Kawanami Akiko author non-byline.; Takase Shunya author non-byline.; Koga Chie author non-byline.; Fukuoka Hideoki author non-byline.; Nakamura Kiminori author non-byline.; Shinohara Kazuyuki author non-byline.; Kakeyama Masaki author non-byline.; Doi Hirokazu author non-byline.; Sawano Erika author non-byline.; Tsuji Toshio author non-byline.; Soh Zu author non-byline.; Shimatani Koji author non-byline.; Yamaguchi Satoru author non-byline.; Onodera Tsutomu author non-byline.; Yamada Takuhiro author non-byline.
• Is Part Of: BMJ open. Volume 6:Issue 1(2016)
• Publication Date: 2016-01-29
• Subjects: Birth cohort -- Children -- Environmental chemicals -- Pregnant women; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2015-010531
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Purpose: Recent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of non-communicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors—particularly the fetal environment and postbirth living environment—on children's health, and to identify potential biomarkers for these effects. Participants: The C-MACH consists of three hospital-based cohorts. The study participants are pregnant women at <13 weeks gestation. Women who underwent an examination in one of the three hospitals received an explanation of the study. The participants consented to completing questionnaire surveys and the collection and storage of biological and house/environmental samples. Participants were provided unique study numbers. All of the data and biological specimens will be stored in the Chiba University Center for Preventive Medical Sciences and Chiba University Center for Preventive Medical Sciences BioBank, respectively. Findings to date: Consent to participate was obtained from 433 women. Of these women, 376 women completed questionnaires in the early gestational period. The mean age was 32.5 (4.4) years. The mean body mass index (BMI) was 21.1 (3.0) kg/m 2 . Before pregnancy, 72.3% of the women had a BMI of 18.5–24.9 kg/m 2 . During early pregnancy, 5.0% of the participants smoked. Future plans: Primary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.