Application of Divide and Conquer Extended Genetic Algorithm to Tertiary Protein Structure of Chymotrypsin Inhibitor-2. Issue 4 (8th July 2010)

• Record Type: Journal Article
• Authors: Alfaro, A.; Doan, M.; Finke, J.; Galdes, M.; Zohdy, M.
• Is Part Of: Applied bionics and biomechanics. Volume 3:Issue 4(2006)
• Page Start: 263
• Page End: 271
• Publication Date: 2010-07-08
• Subjects: Protein folding -- Genetic Algorithm -- Genetic Algorithm for protein folding -- protein folding of chymotrypsin inhibitor-2 -- protein folding of chymotrypsin inhibitor-2 using Genetic Algorithms; Bionics -- Periodicals; Biomechanics -- Periodicals; Biomedical engineering -- Periodicals; 003.505
• DOI: 10.1533/abbi.2006.0038
• Languages: English
• ISSNs: 1176-2322

Abstract

Abstract : Determining the method by which a protein thermodynamically folds and unfolds in three-dimension is one of the most complex and least understood problems in modern biochemistry. Misfolded proteins have been recently linked to diseases including Amyotrophic Lateral Sclerosis and Alzheimer's disease. Because of the large number of parameters involved in defining the tertiary structure of proteins, based on free energy global minimisation, we have developed a new Divide and Conquer (DAC) Extended Genetic Algorithm. The approach was applied to explore and verify the energy landscape of protein chymotrypsin inhibitor-2.