Varying occurrence of gastroduodenal immunoreactive pancreatic secretory trypsin inhibitor. Issue 11 (November 1987)

• Record Type: Journal Article
• Authors: Bohe, M; Lindström, C G; Ohlsson, K
• Is Part Of: Journal of clinical pathology. Volume 40:Issue 11(1987)
• Page Start: 1345
• Page End: 1348
• Publication Date: 1987-11
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.40.11.1345
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Operative specimens from various parts of gastroduodenal mucosa were analysed for immunoreactive pancreatic secretory trypsin inhibitor (PSTI) using a peroxidase-antiperoxidase method. Normal gastric mucosa exhibited a varying degree of PSTI immunoreactivity, which was more pronounced in the foveolar cells of gastric mucosa of fundus type than in the non-pepsinogen producing antrum-pyloric mucosa. With the exception of metaplastic Paneth cells and some goblet cells, the intracellular content of PSTI was low in gastric mucosa with intestinal metaplasia. These findings may indicate that a PSTI immunoreactive substance has a role in the normal defence of the gastric mucosa.