Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis. Issue 6 (June 1974)

• Record Type: Journal Article
• Authors: Claveria, L. E.; Curzon, G.; Harrison, M. J. G.; Kantamaneni, B. D.
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 37:Issue 6(1974)
• Page Start: 715
• Page End: 718
• Publication Date: 1974-06
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.37.6.715
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Mean homovanillic acid and 5-hydroxyindoleacetic acid concentrations were significantly low in the lumbar CSF of a group of patients with disseminated sclerosis (DS) who were severely disabled but not in the CSF of a less severely restricted group with DS. CSF concentrations were also low in a group of patients with superior cerebellar peduncular tremor due to DS and in a single patient with a similar tremor associated with a post-traumatic brain-stem lesion. The interpretation of abnormal CSF amine metabolite concentrations is discussed in the light of these findings.