First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases. Issue 817 (November 1993)

• Record Type: Journal Article
• Authors: Kendra, J. R.; Rugman, F. P.; Flaherty, T. A.; Myers, A.; Horsfield, N.; Barton, A.; Russell, L.
• Is Part Of: Postgraduate medical journal. Volume 69:Issue 817(1993)
• Page Start: 885
• Page End: 887
• Publication Date: 1993-11
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.69.817.885
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role for such cytokine therapy in patients with life-threatening agranulocytosis in order to speed the recovery of neutrophils.