A rapid, simple assay for digoxin. Issue 6 (June 1974)

• Record Type: Journal Article
• Authors: Greenwood, Helena; Howard, M.; Landon, J.
• Is Part Of: Journal of clinical pathology. Volume 27:Issue 6(1974)
• Page Start: 490
• Page End: 494
• Publication Date: 1974-06
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.27.6.490
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : An extremely rapid radioimmunoassay for digoxin is described which is precise over the range of concentrations required to determine whether, or not, a patient has digoxin toxicity. The assay is based on the use of 125 -iodine-labelled digoxin and of a gel equilibration technique for the separation of antibody-bound and free digoxin. The results obtained compare closely with those by a conventional radioimmunoassay and the technique is sufficiently simple to enable its performance by relatively inexperienced laboratory staff.