Stimulation of exocrine pancreatic secretion by met-enkephalin. Issue 12 (December 1986)

• Record Type: Journal Article
• Authors: Gullo, L; Priori, P; Baldoni, F; Mattioli, G
• Is Part Of: Gut. Volume 27:Issue 12(1986)
• Page Start: 1479
• Page End: 1483
• Publication Date: 1986-12
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.27.12.1479
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : The effect of met-enkephalin on pure exocrine pancreatic secretion was studied in five subjects with external transduodenal drainage of the main pancreatic duct carried out after biliary tract surgery. Intravenous infusion of a low dose of met-enkephalin (0.15 micrograms/kg/h) during submaximal pancreatic stimulation with secretin (25 ng/kg/h) and cerulein (10 ng/kg/h) significantly increased pancreatic outputs. Bicarbonate secretion increased 50% above control values, a more marked effect than the increase in enzyme secretion (maximal rise averaged 22%). The effect of the peptide was rapid, persisted for the duration of met-enkephalin infusion and then tended gradually to diminish.