Penetration into bone and tissues of clindamycin phosphate. Issue 628 (February 1978)

• Record Type: Journal Article
• Authors: Baird, P.; Hughes, S.; Sullivan, M.; Willmot, I.
• Is Part Of: Postgraduate medical journal. Volume 54:Issue 628(1978)
• Page Start: 65
• Page End: 67
• Publication Date: 1978-02
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.54.628.65
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Clindamycin phosphate is an antibiotic which is effective against both Staphylococcus aureus and the anaerobic organisms. In thirteen patients, its concentration following joint replacement was measured by the agar diffusion method. In bone, the concentration was (mean +/- s.e. mean) 5.01 microgram/ml +/- 1.16, N=10; in capsule, 3.29 microgram/ml +/- 0.71, N=12; measured between 1.75 and 3.75 hr after intramuscular and intravenous injections, and in drainage fluid it amounted to 4.61 microgram/ml +/- 0.38, N=11 in 48 hr. Two patients developed diarrhoea which settled within a short period.