Characteristics of spontaneously proliferating mononuclear cells in rheumatoid arthritis. Issue 5 (October 1984)

• Record Type: Journal Article
• Authors: Froebel, K; Dickson, R; Lewis, D; Jasani, M K; Sturrock, R D
• Is Part Of: Annals of the rheumatic diseases. Volume 43:Issue 5(1984)
• Page Start: 703
• Page End: 709
• Publication Date: 1984-10
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.43.5.703
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : The phenomenon of increased spontaneous incorporation of 3H-thymidine (3H-TdR) into peripheral blood mononuclear cells in rheumatoid arthritis (RA) has been investigated. The activity was found to be short lived and affected less than 1% of cells. Using a Percoll density gradient we identified two populations of active cells. RA patients with active synovitis and increased 3H-TdR incorporation in the low density population of cells have higher overall 3H-TdR incorporation than normal controls and patients with inactive RA. The low density cell population is enriched for Ia+ cells. The data are consistent with raised spontaneous 3H-TdR incorporation being due to an in-vivo cell mediated immune response.