Clinical evaluation of clobetasone butyrate: a comparative study of its effects in postoperative inflammation and on intraocular pressure. Issue 1 (January 1980)

• Record Type: Journal Article
• Authors: Ramsell, T G; Bartholomew, R S; Walker, S R
• Is Part Of: British journal of ophthalmology. Volume 64:Issue 1(1980)
• Page Start: 43
• Page End: 45
• Publication Date: 1980-01
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.64.1.43
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Clobetasone butyrate, a new corticosteroid with a high topical activity, has been compared with prednisolone phosphate and a placebo in the treatment of inflammation following cataract extraction. These 2 steroids were more effective in relieving postoperative inflammation than placebo (P less than 0.05), though no obvious clinical differences between the 2 compounds emerged from this investigation. However, a single-blind comparative study against betamethasone phosphate in patients suspected of having steroid-induced glaucoma showed that, while betamethasone phosphate significantly raised intraocular pressure, clobetasone butyrate had only a minimal effect, and this difference was statistically significant (P less than 0.02).