Polymorphisms of CD14 gene and TLR4 gene are not associated with ulcerative colitis in Chinese patients. Issue 958 (5th August 2005)

• Record Type: Journal Article
• Authors: Guo, Q S; Xia, B; Jiang, Y; Morré, S A; Cheng, L; Li, J; Crusius, J B A; Peña, A S
• Is Part Of: Postgraduate medical journal. Volume 81:Issue 958(2005)
• Page Start: 526
• Page End: 529
• Publication Date: 2005-08-05
• Subjects: UC, ulcerative colitis -- CD, Crohn's disease -- IBD, inflammatory bowel disease -- TLR4, toll-like receptor 4 -- LBP, LPS binding protein; gene polymorphism -- toll-like receptor-4 -- CD14 -- ulcerative colitis; Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.2004.030825
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Background and aims: Toll-like receptor 4 and CD14 are the components of the lipopolysaccharide receptor complex. The aim of this study was to investigate the associations between polymorphisms TLR4 Asp299Gly and CD14 C-260T and Chinese patients with ulcerative colitis (UC). Methods: Using a polymerase chain reaction based restriction fragment length polymorphism, the study genotyped polymorphisms TLR4 Asp299Gly and CD14 C-260T in 114 patients with UC and 160 healthy controls in the Chinese Han population. Moreover a comparison was made with 170 healthy Dutch white subjects. Results: No TLR4 Asp299Gly mutation was detected in any patients or healthy controls in the Chinese Han population, which was similar to Japanese subjects, but the mutation occurred in 10% of the Dutch white subjects. There were no significant differences of CD14 genotypes between healthy controls and the patients with UC.