Progressive multifocal leucoencephalopathy, sclerosing cholangitis, bronchiectasis and disseminated warts in a patient with primary combined immune deficiency. Issue 7 (July 1992)

• Record Type: Journal Article
• Authors: Misbah, S A; Spickett, G P; Zeman, A; Esiri, M M; Wallington, T B; Kurtz, J B; Chapel, H M
• Is Part Of: Journal of clinical pathology. Volume 45:Issue 7(1992)
• Page Start: 624
• Page End: 627
• Publication Date: 1992-07
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.45.7.624
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A 24 year old man presented with an unusual primary combined immune deficiency syndrome characterised by a profound lymphopenia of CD4 cells, selective serum IgG2 subclass deficiency, poor polysaccharide antibody responses, disseminated warts, recurrent sinopulmonary infection and bronchiectasis. The developed progressive multifocal leucoencephalopathy (PML) in association with sclerosing cholangitis. Progressive multifocal leucoencephalopathy (PML) usually occurs as an opportunistic infection in patients with secondary defects in cellular immunity.