Onset age and severity of motor impairment are associated with reduction of myocardial 123I-MIBG uptake in Parkinson's disease. Issue 4 (1st April 2003)

• Record Type: Journal Article
• Authors: Hamada, K; Hirayama, M; Watanabe, H; Kobayashi, R; Ito, H; Ieda, T; Koike, Y; Sobue, G
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 74:Issue 4(2003)
• Page Start: 423
• Page End: 426
• Publication Date: 2003-04-01
• Subjects: 123I-metaiodobenzylguanidine -- Parkinson's disease -- age -- onset; H-Y, Hoehn and Yahr -- MIBG, 123I-metaiodobenzylguanidine -- PD, Parkinson's disease; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.74.4.423
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Objectives: To elucidate the factors associated with severity of cardiac sympathetic nerve involvement in idiopathic Parkinson's disease (PD). Methods: 123 I-metaiodobenzylguanidine uptake was examined in 88 patients with PD. The ratio of the uptake in the heart ( H ) to that in the mediastinum (M) (the H / M ratio) was calculated and correlated with age at onset, age at examination, and disease severity and duration. Twenty five healthy people were also examined as a control. Results: There was a mild but significant negative correlation between H / M ratio and age at onset (early, r = −0.33, p = 0.002; delayed, r = −0.34, p = 0.001) and between Hoehn and Yahr (H-Y) stage (early, r = −0.30, p = 0.006; delayed, r = −0.32, p = 0.003). There was no significant correlation between disease duration and H / M ratio. When patients with PD were classified into four subgroups on the basis of age at onset (> 62 or < 62 years) and disease severity (H-Y > III or H-Y ⩽ II), the median H / M ratio of the older and more severe group was significantly lower than that of the younger and less severe group (p = 0.005). Conclusion: This study suggests that late onset, high severity PD is associated with myocardial sympathetic dysfunction.