Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections. Issue 3 (1st June 2001)

• Record Type: Journal Article
• Authors: White, D J; Habib, A R; Vanthuyne, A; Langford, S; Symonds, M
• Is Part Of: Sexually transmitted infections. Volume 77:Issue 3(2001)
• Page Start: 212
• Page End: 213
• Publication Date: 2001-06-01
• Subjects: amphotericin -- flucytosine -- Candida glabrata; Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sti.77.3.212
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : Patients with vaginitis due to highly azole resistant Candida glabrata can be particularly difficult to treat. We describe three cases of longstanding vaginal candidiasis due to C glabrata . These had failed to respond to local and systemic antifungals. Flucytosine (1 g) and amphotericin B (100 mg) formulated in lubricating jelly base in a total 8 g delivered dose, was used per vagina once daily for 14 days with significant improvement, both clinically and microbiologically.