Selective D-1 dopamine receptor agonist effects in hyperkinetic extrapyramidal disorders. Issue 5 (May 1989)

• Record Type: Journal Article
• Authors: Braun, A; Mouradian, M M; Mohr, E; Fabbrini, G; Chase, T N
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 52:Issue 5(1989)
• Page Start: 631
• Page End: 635
• Publication Date: 1989-05
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.52.5.631
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : The motor and cognitive effects of a selective D-1 dopamine receptor agonist, SKF 39393, were assessed in patients with Huntington's disease, Gilles de la Tourette's syndrome, tardive dyskinesia, and torsion dystonia, using a double-blind placebo-controlled design. Over daily doses ranging from 3.2 to 32 mg/kg and treatment intervals extending from one to seven weeks, no consistent changes could be discerned. The contribution of D-1 receptor mediated mechanisms to the pathophysiology of hyperkinetic extrapyramidal disorders remains uncertain.