Disseminated toxoplasmosis in cardiac transplantation. Issue 1 (January 1984)

• Record Type: Journal Article
• Authors: McGregor, C G; Fleck, D G; Nagington, J; Stovin, P G; Cory-Pearce, R; English, T A
• Is Part Of: Journal of clinical pathology. Volume 37:Issue 1(1984)
• Page Start: 74
• Page End: 77
• Publication Date: 1984-01
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.37.1.74
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : The first case of disseminated toxoplasmosis following cardiac transplantation in the UK is described, with details of Toxoplasma antibody tests made on other cardiac transplant patients. Sixteen of 40 (39%) of recipients had Toxoplasma antibody before operation. Eleven of 30 (37%) of donors had Toxoplasma antibody. The were four occasions when a negative recipient received a heart from a positive donor. Three survived the immediate postoperative period and two became infected with toxoplasmosis. The implications of this are discussed. Disseminated toxoplasmosis appears much more often when heart muscle from a dye test positive donor is given to a dye test negative recipient. Antibiotic therapy is limited by the fact that the antitoxoplasma drugs available are static in their effect, and need to be given for prolonged periods postoperatively.