Cardiovascular response to physical exercise in adult patients after atrial correction for transposition of the great arteries assessed with magnetic resonance imaging. (14th May 2004)

• Record Type: Journal Article
• Authors: Roest, A A W; Lamb, H J; van der Wall, E E; Vliegen, H W; van den Aardweg, J G; Kunz, P; de Roos, A; Helbing, W A
• Is Part Of: Heart. Volume 90(2004)Supplement 6
• Page Start: 678
• Page End: 684
• Publication Date: 2004-05-14
• Subjects: exercise -- magnetic resonance imaging -- cardiac function -- transposition of the great arteries -- atrial correction; MRI, magnetic resonance imaging -- NYHA, New York Heart Association -- TFEPI, turbofield echo planar imaging -- TGA, transposition of the great arteries; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2003.023499
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To assess with magnetic resonance imaging (MRI) cardiovascular function in response to exercise in patients after atrial correction of transposition of the great arteries (TGA). Methods: Cardiac function at rest and during submaximal exercise was assessed with MRI in 27 patients with TGA (mean (SD) age 26 (5) years) late (23 (2) years) after atrial correction and in 14 control participants (25 (5) years old). Results: At rest, only right ventricular ejection fraction was significantly lower in patients than in controls (56 (7)% v 65 (7)%, p < 0.05). In response to exercise, increases in right ventricular end diastolic (155 (55) ml to 163 (57) ml, p < 0.05) and right ventricular end systolic volumes (70 (34) ml to 75 (36) ml, p < 0.05) were observed in patients. Furthermore, right and left ventricular stroke volumes and ejection fraction did not increase significantly in patients. Changes in right ventricular ejection fraction with exercise correlated with diminished exercise capacity ( r = 0.43, p < 0.05). Conclusions: In patients with atrially corrected TGA, MRI showed an abnormal response to exercise of both systemic right and left ventricles. Exercise MRI provides a tool for close monitoring of cardiovascular function in these patients, who are at risk for late death.