Peliosis hepatis induced by 6-thioguanine administration. Issue 9 (September 1988)

• Record Type: Journal Article
• Authors: Larrey, D; Fréneaux, E; Berson, A; Babany, G; Degott, C; Valla, D; Pessayre, D; Benhamou, J P
• Is Part Of: Gut. Volume 29:Issue 9(1988)
• Page Start: 1265
• Page End: 1269
• Publication Date: 1988-09
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.29.9.1265
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : A patient with acute myeloblastic leukaemia developed jaundice revealing peliosis hepatis after receiving 6-thioguanine for two months. Peliosis hepatis was severe and was associated with mild lesions of centrilobular veins. Withdrawal of 6-thioguanine was followed by a progressive improvement of liver dysfunction. This report shows that 6-thioguanine, a thiopurine already reported to be responsible for veno-occlusive disease of the liver, can induce peliosis hepatis. This suggests that some liver vascular disorders caused by thiopurines (6-thioguanine, azathioprine and 6-mercaptopurine), particularly peliosis hepatis, veno-occlusive disease, sinusoidal dilatation and perisinusoidal fibrosis, might be related syndromes caused by similar lesions at different sites.