New Insights into the Cellular and Molecular Mechanisms of Cold Storage Injury. (1st July 2004)

• Record Type: Journal Article
• Authors: Rauen, Ursula; de Groot, Herbert
• Is Part Of: Journal of investigative medicine. Volume 52:Number 5(2004)
• Page Start: 299
• Page End: 309
• Publication Date: 2004-07-01
• Subjects: cold ischemia -- hypothermia -- organ preservation; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.1136/jim-52-05-29
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Solid organ grafts, but also other biologic materials requiring storage for a few hours to a few days, are usually stored under hypothermic conditions. To decrease graft injury during cold storage, organ preservation solutions were developed many years ago. However, since then, modern biochemical and cell biologic methods have allowed further insights into the molecular and cellular mechanisms of cold storage injury, including further insights into alterations of the cellular ion homeostasis, the occurrence of a mitochondrial permeability transition, and the occurrence of free-radical-mediated hypothermic injury and cold-induced apoptosis. These new aspects of cold storage injury, which are not covered by preservation solutions in current clinical use and offer the potential for improvement of organ and tissue preservation, are presented here.