Bone marrow aplasia in B cell chronic lymphocytic leukaemia: successful treatment with antithymocyte globulin. Issue 11 (November 1991)

• Record Type: Journal Article
• Authors: Singal, R; Winfield, D A; Greaves, M
• Is Part Of: Journal of clinical pathology. Volume 44:Issue 11(1991)
• Page Start: 954
• Page End: 956
• Publication Date: 1991-11
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.44.11.954
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Pure red cell aplasia is a rare but well known association of chronic lymphocytic leukaemia (CLL). Pancytopenia due to bone marrow aplasia has not been previously described in CLL. A 42 year old man with B cell CLL became severely pancytopenic with bone marrow aplasia. Bone marrow culture resulted in a greatly reduced colony formation. High dose corticosteroids and intravenous immunoglobulin treatment were unsuccessful. Prompt and complete marrow recovery ensued after administration of antithymocyte globulin.