Lymphocytotoxins in rheumatoid arthritis: prevalence, lymphocyte specificity, and HLA-DR antigens. Issue 2 (April 1981)

• Record Type: Journal Article
• Authors: Wooley, P H; Panayi, G S; Batchelor, J R
• Is Part Of: Annals of the rheumatic diseases. Volume 40:Issue 2(1981)
• Page Start: 154
• Page End: 156
• Publication Date: 1981-04
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.40.2.154
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : 37% (57/155) of sera from patients with rheumatoid arthritis contain cold-reacting lymphocytotoxic antibodies. Lymphocytotoxins were predominantly of the weakly reactive type and were more likely to be present in patients who were HLA-DR4 positive. By contrast, patients who were HLA-DR3 positive were more likely to have strongly reactive lymphocytotoxins. The lymphocyte subclass reactivity of the lymphocytotoxins was: 67% versus B lymphocytes, 27% against both T and B cells, and 7% for T cells.