Expression of calcitonin receptor-like receptor in human vascular tumours. Issue 10 (4th October 2006)

• Record Type: Journal Article
• Authors: Hagner, S; Stahl, U; Grimm, T; Stürzl, M; Lang, R E
• Is Part Of: Journal of clinical pathology. Volume 59:Issue 10(2006)
• Page Start: 1104
• Page End: 1107
• Publication Date: 2006-10-04
• Subjects: ADM, adrenomedullin -- CRLR, calcitonin receptor-like receptor -- CRLR-LI, calcitonin receptor-like receptor-like immunoreactivity -- PCR, polymerase chain reaction -- RAMP, receptor activity-modifying protein -- VEGF, vascular endothelial-derived growth factor; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.2005.026930
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Background: Vascular tumours such as Kaposi's sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis. Aim: To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours. Methods: CRLR expression was investigated in several specimens of Kaposi's sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction. Results: Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium. Conclusions: CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth.