Analysis of human herpes virus-6 genomes in lymphoid malignancy in Japan. Issue 12 (December 1993)

• Record Type: Journal Article
• Authors: Sumiyoshi, Y; Kikuchi, M; Ohshima, K; Takeshita, M; Eizuru, Y; Minamishima, Y
• Is Part Of: Journal of clinical pathology. Volume 46:Issue 12(1993)
• Page Start: 1137
• Page End: 1138
• Publication Date: 1993-12
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.46.12.1137
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Ninety cases of malignant lymphoma and 56 cases of reactive lymphadenopathy were studied using Southern blot analysis and the polymerase chain reaction to identify human herpes virus-6 (HHV-6) DNA. This was detected in cases of lymphoid malignancy at a rate which ranged from 50.0% to 68.8%. There were no differences in rates for different types of lymphoid malignancies. Herpes virus-6 DNA was detected by PCR in lymphoid malignancies less frequently than in reactive lymphadenopathies. It was not detected in lymphoid malignancies using Southern blotting. These results suggest that HHV-6 DNA was not related to lymphoid malignancy and was only a latent infection of non-neoplastic cells in tumour tissue.