HLA-DR expression by labial minor salivary gland tissues in Sjögren's syndrome. Issue 8 (August 1986)

• Record Type: Journal Article
• Authors: Moutsopoulos, H M; Hooks, J J; Chan, C C; Dalavanga, Y A; Skopouli, F N; Detrick, B
• Is Part Of: Annals of the rheumatic diseases. Volume 45:Issue 8(1986)
• Page Start: 677
• Page End: 683
• Publication Date: 1986-08
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.45.8.677
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Minor salivary gland biopsy specimens from patients with Sjögren's syndrome (primary and secondary) and from normal controls were examined with the four step biotin-avidin-immunoperoxidase assay. The composition of the infiltrating cells was similar in patients with both primary and secondary Sjögren's syndrome, consisting primarily of T lymphocytes with predominance of T helper/inducer cells. B lymphocytes (Leu-14) were approximately 20-35% of the infiltrating lymphocytes, while only a few OKM1 (monocytes/macrophages) cells and Leu-7+ (natural killer; NK) cells were observed. The majority of infiltrating lymphocytes expressed HLA-DR antigens. In the biopsy specimens of the controls there were no infiltrates; the scattered lymphocytes, however, were also predominantly T lymphocytes. Finally, the glandular epithelial cells (ducts and acini) were inappropriately expressing HLA-DR antigens, in contrast with controls where minimal HLA-DR expression was found.