Mycophenolate mofetil inhibits human Tenon fibroblast proliferation by guanosine depletion. Issue 11 (10th November 2003)

• Record Type: Journal Article
• Authors: Heinz, C; Heise, K; Hudde, T; Steuhl, K-P
• Is Part Of: British journal of ophthalmology. Volume 87:Issue 11(2003)
• Page Start: 1397
• Page End: 1398
• Publication Date: 2003-11-10
• Subjects: mycophenolate mofetil -- fibroblast proliferation -- guanosine depletion; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.87.11.1397
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Backgroundaim: Mycophenolate mofetil could be a useful antiproliferative drug in glaucoma filtering surgery. In this study the authors set out to investigate whether growth inhibition of mycophenolate mofetil on human Tenon fibroblasts is mediated by guanosine depletion. Methods: Cultured human Tenon fibroblasts were incubated in various concentrations of mycophenolate mofetil with and without supplementation of guanosine. Results: Growth inhibition was concentration dependent. The effect could be completely antagonised by guanosine supplement. Conclusion: Human Tenon fibroblasts depend on the de novo synthesis pathway of guanosine. No sufficient salvage pathway from purine degradation appears to exist.